High Dose Vitamin C For Allergies

Vernon Desember 03, 2021

High Dose Vitamin C For Allergies

Clinical Trial

. 2018 Sep;46(9):3640-3655.

doi: 10.1177/0300060518777044. Epub 2018 Jun 27.

Intravenous vitamin C in the treatment of allergies: an interim subgroup analysis of a long-term observational study

Affiliations

  • PMID: 29950123
  • PMCID: PMC6136002
  • DOI: 10.1177/0300060518777044

Free PMC article

Clinical Trial

Intravenous vitamin C in the treatment of allergies: an interim subgroup analysis of a long-term observational study

Claudia Vollbracht  et al. J Int Med Res. 2018 Sep .

Free PMC article

Abstract

Objective Oxidative stress appears to be a key factor in the pathogenesis of allergic diseases and a potential therapeutic target in allergy treatment. Allergic diseases are reportedly associated with reduced plasma levels of ascorbate, which is a key physiological antioxidant. Ascorbate prevents excessive inflammation without reducing the defensive capacity of the immune system. Methods An interim analysis of a multicenter, prospective, observational study was conducted to investigate the change in disease-specific and nonspecific symptoms (fatigue, sleep disorders, depression, and lack of mental concentration) during adjuvant treatment with intravenous vitamin C (Pascorbin®; Pascoe, Giessen, Germany) in 71 patients with allergy-related respiratory or cutaneous indications. Results Between the start and end of treatment, the mean sum score of three disease-specific symptoms decreased significantly by 4.71 points and that of four nonspecific symptoms decreased significantly by 4.84 points. More than 50% of patients took no other allergy-related medication besides vitamin C. Conclusions Our observations suggest that treatment with intravenous high-dose vitamin C reduces allergy-related symptoms. Our observations form a basis for planning a randomized controlled clinical trial to obtain more definitive evidence of the clinical relevance of our findings. We also obtained evidence of ascorbate deficiency in allergy-related diseases.

Trial registration: Clinical Trials NCT02422901.

Keywords: Ascorbic acid; allergic asthma; allergic rhinitis; dermatitis; eczema; human; intravenous administration; pruritus.

Figures

Figure 1.
Figure 1.

Flowchart of study patients.

Figure 2.
Figure 2.

Frequencies of the three most frequently recorded disease-specific symptoms. The severity of each symptom was documented on a 4-point Likert scale (0 = absent, 1 = mild, 2 = moderate, 3 = severe) by the treating physician or natural health practitioner at start and end of treatment. Valid data for pruritus, n = 31; for rhinitis, n = 26; and for restlessness, n = 15.

Figure 3.
Figure 3.

Frequency of nonspecific symptoms (tiredness/fatigue, sleep disorders, depression, and lack of mental concentration). The severity of each symptom was documented on a 4-point Likert scale (0 = absent, 1 = mild, 2 = moderate, 3 = severe) by the treating physician or natural health practitioner at start and end of treatment. Valid data for tiredness/fatigue, n = 62; for sleep disorders, n = 53; for depression, n = 44; and for lack of mental concentration, n = 60.

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High Dose Vitamin C For Allergies

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